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Cpt1c Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8TCG5 |
| Other Accession | Q8TCG5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 90989 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Cpt1c |
| Epitope Specificity | 121-170/803 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the carnitine/choline acetyltransferase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine. |
| Gene ID | 126129 |
|---|---|
| Other Names | CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B; CPTIC; SPG73; 6530437J22Rik; 9630004I06Rik; CPT IC; CPT1C_HUMAN; CPT1C; Carnitine O-palmitoyltransferase 1, brain isoform (CPTI-B); Carnitine palmitoyltransferase 1C; Carnitine palmitoyltransferase I (CPT I-C); 3.1.2.22; CPT1C_MOUSE; CPT1C_RAT; Carnitine O-palmitoyltransferase 1, brain isoform (CPT1-B); Carnitine O-palmitoyltransferase I, brain isoform (CPTI-B) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CPT1C (HGNC:18540) |
|---|---|
| Synonyms | CATL1 |
| Function | Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (PubMed:30135643). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:25751282, PubMed:30135643). |
| Cellular Location | Cell projection, dendrite. Cell projection, axon. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized in the soma and dendritic and axonal projections. |
| Tissue Location | Expressed predominantly in brain and testis. Expressed in motor neurons. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97773
