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CLIP2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UDT6 |
| Other Accession | Q9UDT6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 115837 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CYLN2 |
| Epitope Specificity | 901-1046/1046 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 CAP-Gly domains. |
| SUBUNIT | Interacts with CLASP1 and CLASP2. |
| DISEASE | Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] |
| Gene ID | 7461 |
|---|---|
| Other Names | CLIP; CLIP-115; CYLN2; WBSCR3; WBSCR4; WSCR3; WSCR4; B230327O20; Clip1; mKIAA0291; CLIP2_HUMAN; CLIP2; Cytoplasmic linker protein 115 (CLIP-115); Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein; KIAA0291; CLIP2_MOUSE; CLIP2_RAT; CAP-Gly domain containing linker protein 2; cytoplasmic linker 2; Williams-Beuren syndrome chromosome region 3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CLIP2 |
|---|---|
| Synonyms | CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4 |
| Function | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O55156}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z0H8}. Note=Localizes preferentially to the ends of tyrosinated microtubules {ECO:0000250|UniProtKB:Q9Z0H8} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP97783
