癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZNF743 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BQA5 |
| Other Accession | Q9BQA5 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit, Chicken, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59678 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZNF743 |
| Epitope Specificity | 301-400/517 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 9 C2H2-type zinc fingers. |
| Post-translational modifications | Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011] |
| Gene ID | 25988 |
|---|---|
| Other Names | MIZF; HiNF-P; ZNF743; RGD1311492; HINFP_BOVIN; HINFP; Histone nuclear factor P (HiNF-P); MBD2-interacting zinc finger protein; Methyl-CpG-binding protein 2-interacting zinc finger protein; HINFP_HUMAN; HINFP_MOUSE; histone H4 transcription factor; MBD2-interacting zinc finger 1; MBD2-interacting zinc finger; histone nuclear factor P |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HINFP |
|---|---|
| Synonyms | MIZF, ZNF743 |
| Function | Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. |
| Cellular Location | Nucleus. Note=Associated with discrete nuclear foci |
| Tissue Location | Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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