癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HINFP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BQA5 |
| Other Accession | NP_945322.1, NP_056332.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59678 Da |
| Antigen Region | 317-346 aa |
| Gene ID | 25988 |
|---|---|
| Other Names | Histone H4 transcription factor, Histone nuclear factor P, HiNF-P, MBD2-interacting zinc finger protein, Methyl-CpG-binding protein 2-interacting zinc finger protein, HINFP, MIZF, ZNF743 |
| Target/Specificity | This HINFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the Central region of human HINFP. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HINFP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HINFP |
|---|---|
| Synonyms | MIZF, ZNF743 |
| Function | Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. |
| Cellular Location | Nucleus. Note=Associated with discrete nuclear foci |
| Tissue Location | Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MIZF interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Mitra, P., et al. J. Cell. Physiol. 219(2):438-448(2009)
Medina, R., et al. Biochemistry 47(44):11415-11423(2008)
Medina, R., et al. Cancer Res. 67(21):10334-10342(2007)
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