癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PBLD Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P30039 |
| Other Accession | P30039 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31785 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PBLD/MAWBP |
| Epitope Specificity | 31-140/288 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the phzF family. |
| SUBUNIT | Interacts with UNRIP/MAWD. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MAWDBP (MAWD binding protein), also known as PBLD (phenazine biosynthesis-like protein domain containing) or MAWBP, is a 288 amino acid protein that belongs to the phenazine biosynthesis-like protein (PhzF) family. It has been suggested that MAWDBP is the only representative of the PhzF family in the human genome. Expressed in most tissues, MAWDBP is a WD-40 repeat-containing β-propeller protein believed to participate in the MAPK signaling pathway. Involved in multiple basic cellular functions, expression of MAWDBP is elevated in several disease processes, including insulin resistance, folate deficiency and hypotension. It is thought that MAWDBP may also be involved in carcinogenesis. |
| Gene ID | 64081 |
|---|---|
| Other Names | HEL-S-306; MAWBP; MAWDBP; PBLD_HUMAN; PBLD; MAWD-binding protein (MAWDBP); Unknown protein 32 from 2D-page of liver tissue; 5.1.-.-; phenazine biosynthesis like protein domain containing; phenazine biosynthesis-like protein domain containing; MAWD binding protein |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PBLD (HGNC:23301) |
|---|---|
| Synonyms | MAWBP |
| Function | Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response (PubMed:39362857, PubMed:39589880, PubMed:39779683). PBLD enhances IFN-I signaling via multiple pathways (PubMed:39362857, PubMed:39589880, PubMed:39779683). Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication (PubMed:39362857). Up-regulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (PubMed:39779683). Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection (PubMed:39589880). Acts as a tumor suppressor, regulating development of various cancers (PubMed:23687415, PubMed:26594798). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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