癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PBLD Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P30039 |
| Other Accession | NP_071412.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31785 Da |
| Antigen Region | 242-269 aa |
| Gene ID | 64081 |
|---|---|
| Other Names | Phenazine biosynthesis-like domain-containing protein, 51--, MAWD-binding protein, MAWDBP, Unknown protein 32 from 2D-page of liver tissue, PBLD, MAWBP |
| Target/Specificity | This PBLD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the C-terminal region of human PBLD. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PBLD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PBLD (HGNC:23301) |
|---|---|
| Synonyms | MAWBP |
| Function | Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response (PubMed:39362857, PubMed:39589880, PubMed:39779683). PBLD enhances IFN-I signaling via multiple pathways (PubMed:39362857, PubMed:39589880, PubMed:39779683). Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication (PubMed:39362857). Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (PubMed:39779683). Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection (PubMed:39589880). Acts as a tumor suppressor, regulating development of various cancers (PubMed:23687415, PubMed:26594798). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Belongs to the phzF family.
REFERENCES
Macgregor, S., et al. Hum. Mol. Genet. 19(13):2716-2724(2010)
Ramdas, W.D., et al. PLoS Genet. 6 (6), E1000978 (2010) :
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
van Dijk, M., et al. Nat. Genet. 37(5):514-519(2005)
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