癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RHG19 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q14CB8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55756 Da |
| Antigen Region | 195-224 aa |
| Gene ID | 84986 |
|---|---|
| Other Names | Rho GTPase-activating protein 19, Rho-type GTPase-activating protein 19, ARHGAP19 |
| Target/Specificity | This RHG19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the Central region of human RHG19. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RHG19 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ARHGAP19 {ECO:0000303|PubMed:17454002, ECO:0000312|HGNC:HGNC:23724} |
|---|---|
| Function | Has GTPase activator activity toward RHOA; RHOA activation results in GTP hydrolysis and conversion from an active GTP-bound to an inactive GDP-bound state (PubMed:24259668, PubMed:41086021). Lacks GTPase activator activity toward RAC1 or CDC42 (PubMed:24259668). |
| Cellular Location | Nucleus. Cytoplasm Cytoplasm, cell cortex. Note=Localization changes during the cell cycle. In prophase and metaphase, it is dispersed in the cytoplasm; after anaphase onset, it is recruited at the cell cortex, and during cleavage furrow ingression and until the end of telophase, it concentrates at the equatorial cortex |
| Tissue Location | Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary. Expressed in T-lymphocytes; expression varies during the cell cycle and is high at mitosis (PubMed:24259668). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression.
REFERENCES
Lv, L., et al. DNA Seq. 18(3):184-189(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Jikuya, H., et al. DNA Res. 10(1):49-57(2003)
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