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JMJD1B Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q7LBC6 |
| Other Accession | Q7LBC6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 191581 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human JMJD1B |
| Epitope Specificity | 1601-1761/1761 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the JHDM2 histone demethylase family.Contains 1 JmjC domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression. |
| Gene ID | 51780 |
|---|---|
| Other Names | 5qNCA; C5orf7; DIJOS; JMJD1B; NET22; 5830462I21Rik; JHDM2B; mKIAA1082; KDM3B_HUMAN; KDM3B; JmjC domain-containing histone demethylation protein 2B; Jumonji domain-containing protein 1B; Nuclear protein 5qNCA; [histone H3]-dimethyl-L-lysine(9) demethylase 3B; 1.14.11.65; KIAA1082; KDM3B_MOUSE; lysine demethylase 3B; chromosome 5 open reading frame 7; jumonji domain containing 1B; lysine (K)-specific demethylase 3B |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KDM3B |
|---|---|
| Synonyms | C5orf7, JHDM2B, JMJD1B, KIAA1082 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98263
