癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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SKOR2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q2VWA4 |
| Other Accession | Q2VWA4 |
| Reactivity | Rat, Mouse |
| Predicted | Human, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 105809 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SKOR2 |
| Epitope Specificity | 871-970/1001 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the SKI family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-β by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-β in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3. |
| Gene ID | 652991 |
|---|---|
| Other Names | CH18515; CORL2; FUSSEL18; SKOR2_HUMAN; SKOR2; Functional Smad-suppressing element on chromosome 18 (Fussel-18); LBX1 corepressor 1-like protein; Ladybird homeobox corepressor 1-like protein; SKI family transcriptional corepressor 2; functional smad suppressing element 18 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SKOR2 (HGNC:32695) |
|---|---|
| Synonyms | CORL2, FUSSEL18 |
| Function | Has transcriptional corepressor activity. In the developing cerebellum, it down-regulates BMP signaling resulting in up-regulation of SHH expression in Purkinje cells and promoting their early differentiation. It is also involved in regulating the proliferation of cerebellar granule cell precursors. |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,980.00
Cat# AP98324
