癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MTUS2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q5JR59 |
| Other Accession | Q5JR59 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 150195 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MTUS2 |
| Epitope Specificity | 1261-1369/1369 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | In the C-terminal section; belongs to the MTUS1 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. The KIAA0774 gene product has been provisionally designated KIAA0774 pending further characterization |
| Gene ID | 23281 |
|---|---|
| Other Names | CAZIP; ICIS; KIAA0774; TIP150; 5730592G18Rik; A730013O20Rik; C130038G02Rik; Gm763; mKIAA0774; MTUS2_HUMAN; MTUS2; Cardiac zipper protein; Microtubule plus-end tracking protein TIP150 (Tracking protein of 150 kDa); MTUS2_MOUSE; microtubule associated scaffold protein 2; microtubule associated tumor suppressor candidate 2; +TIP of 150 kDa |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MTUS2 |
|---|---|
| Synonyms | CAZIP, KIAA0774, TIP150 |
| Function | Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. |
| Cellular Location | Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules |
| Tissue Location | Detected in embryonic stem cells differentiating to cardiomyocytes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP98346
