癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FASTK Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q14296 |
| Other Accession | Q14296 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61104 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FAST kinase |
| Epitope Specificity | 481-549/549 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the FAST protein kinase family.Contains 1 RAP domain. |
| SUBUNIT | Interacts with TIA-1 and TIAR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis promoting nuclear RNA binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full length natures have not yet been determined. |
| Gene ID | 10922 |
|---|---|
| Other Names | FASTK_HUMAN; FASTK; FAST kinase; 2.7.11.1; 2.7.11.8; FASTK_MOUSE; Fas activated serine/threonine kinase; Fas-activated serine/threonine kinase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FASTK |
|---|---|
| Function | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro- apoptotic form of the receptor. |
| Cellular Location | [Isoform 4]: Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules. |
| Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98479
