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KCC2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H2X9 |
| Other Accession | Q9H2X9 |
| Reactivity | Rat |
| Predicted | Pig, Human, Mouse, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 126184 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCC2 |
| Epitope Specificity | 851-950/1139 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the SLC12A transporter family. |
| SUBUNIT | Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008] |
| Gene ID | 57468 |
|---|---|
| Other Names | DEE34; EIEE34; EIG14; KCC2; hKCC2; mKIAA1176; S12A5_HUMAN; SLC12A5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2 (hKCC2); Neuronal K-Cl cotransporter; KIAA1176; S12A5_MOUSE; K-Cl cotransporter 2 (mKCC2); S12A5_RAT; Furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2 (rKCC2); solute carrier family 12 member 5; solute carrier family 12 (potassium/chloride transporter), member 5; K-Cl cotransporter 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC12A5 (HGNC:13818) |
|---|---|
| Function | Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q91V14}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91V14}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q91V14}. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses. {ECO:0000250|UniProtKB:Q91V14} |
| Tissue Location | Brain specific. Detected in neuronal cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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