癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DRES17 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q86TP1 |
| Other Accession | Q86TP1 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50200 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DRES17 |
| Epitope Specificity | 201-300/453 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the PPase class C family. Prune subfamily. |
| SUBUNIT | Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness. |
| Gene ID | 58497 |
|---|---|
| Other Names | DRES-17; DRES17; H-PRUNE; HTCD37; NMIHBA; PRUNE; 9230112O05Rik; C130058A12; PRUNEM1; Prune-M1; PRUN1_HUMAN; PRUNE1; Drosophila-related expressed sequence 17 (DRES-17 | DRES17); Protein prune homolog 1 (hPrune); 3.6.1.1; PRUN1_MOUSE; prune exopolyphosphatase 1; prune homolog (Drosophila) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PRUNE1 (HGNC:13420) |
|---|---|
| Synonyms | PRUNE |
| Function | Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues (PubMed:18700747). Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates (PubMed:14998490, PubMed:17655525). Requires divalent metal ions for activity (PubMed:14998490, PubMed:18700747). Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1 (PubMed:10602478, PubMed:11687967, PubMed:14998490, PubMed:16428445, PubMed:17906697). Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization (PubMed:28334956). |
| Cellular Location | Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed |
| Tissue Location | Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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