癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NEK1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96PY6 |
| Other Accession | Q96PY6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 142828 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NEK1 |
| Epitope Specificity | 301-400/1258 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. NEK Ser/Thrprotein kinase family. NIMA subfamily.Contains 1 protein kinase domain. |
| SUBUNIT | Binds to SPERT (By similarity). |
| DISEASE | Defects in NEK1 are the cause of short rib-polydactylysyndrome type 2 (SRPS2) [MIM:263520]. A lethal skeletal dysplasiacharacterized by markedly short ribs, short limbs, polydactyly, andmultiple anomalies including a narrow thorax with hypoplasticlungs, extreme polysyndactyly, dysproportionate dwarfism, mediancleft lip and palate, a ventriculoseptal defect and cystic kidneys.The radiographic hallmarks include shortened and horizontal ribs,squared scapulae and elevated clavicles with lateral kinking,normal spine and pelvis configuration, and shortening of the bonesof all four extremities, with extreme reduction of tibial bonelength. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a serine/threoninekinase involved in cell cycle regulation. The encoded protein isfound in a centrosomal complex with FEZ1, a neuronal protein thatplays a role in axonal development. Defects in this gene are acause of polycystic kidney disease (PKD). Several transcriptvariants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2010]. |
| Gene ID | 4750 |
|---|---|
| Other Names | ALS24; NY-REN-55; OFD2; SRPS2; SRPS2A; SRTD6; D8Ertd790e; kat; NEK1_HUMAN; NEK1; Never in mitosis A-related kinase 1 (NimA-related protein kinase 1); Renal carcinoma antigen NY-REN-55; 2.7.11.1; KIAA1901; NEK1_MOUSE; NIMA related kinase 1; NIMA (never in mitosis gene a)-related kinase 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NEK1 |
|---|---|
| Synonyms | KIAA1901 |
| Function | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P51954}. Cytoplasm. Note=Associated with the pericentriolar material (PubMed:21211617). Localizes to centrosome during interphase and mitosis (By similarity). Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage (PubMed:15604234) {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:15604234, ECO:0000269|PubMed:21211617} |
| Tissue Location | High fetal expression in the brain and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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