癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Deltex Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q86Y01 |
| Other Accession | Q86Y01 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67368 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Deltex |
| Epitope Specificity | 351-450/620 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the Deltex family.Contains 1 RING-type zinc finger. Contains 2 WWE domains. |
| SUBUNIT | Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH. |
| Post-translational modifications | Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008] |
| Gene ID | 1840 |
|---|---|
| Other Names | RNF140; hDx-1; Fxit1; mKIAA4160; DTX1_HUMAN; DTX1; Protein deltex-1 (Deltex1 | hDTX1); RING-type E3 ubiquitin transferase DTX1; 2.3.2.27; DTX1_MOUSE; FXI-T1; Protein deltex-1 (Deltex1 | mDTX1); deltex E3 ubiquitin ligase 1; deltex homolog 1 (Drosophila) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DTX1 |
|---|---|
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and proteasomal degradation of MEKK1, thereby modulating signaling pathways involved in cell fate determination (By similarity). Regulates the Notch signaling pathway, acting predominantly as a positive regulator but functioning as a context-dependent negative regulator in specific developmental or cellular settings. Mediates the antineural activity of Notch signaling, likely by inhibiting transcriptional activation mediated by MATCH1. Negatively regulates Notch signaling by controlling the activity of PIP4K2C, a lipid kinase that promotes recycling of Notch receptors from RAB4A-positive endosomes to the cell surface (PubMed:29440432). Participates in several developmental and immune processes, including neurogenesis, lymphogenesis, and myogenesis. Influences lymphocyte differentiation by promoting B-cell development at the expense of T-cell development, suggesting functional antagonism of NOTCH1 in this context. Also promotes degradation of PRKCQ via the endosome-lysosome pathway, contributing to PKCtheta down-regulation during T-cell anergy (PubMed:25000980). In addition, facilitates differentiation of Th17 cells by inducing expression and DNA-binding activity of RORgT (PubMed:32736174). |
| Cellular Location | Cytoplasm. Nucleus. Endosome Note=Predominantly cytoplasmic. Associates with endocytic vesicles Partially nuclear. |
| Tissue Location | Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98914
