癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLAUR Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q03405 |
| Other Accession | Q03405 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36978 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PLAUR |
| Epitope Specificity | 201-300/335 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 3 UPAR/Ly6 domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol(GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]. |
| Gene ID | 5329 |
|---|---|
| Other Names | CD87; U-PAR; UPAR; URKR; Par; Plaur3; uPAR-2; uPAR-3; UPAR_HUMAN; PLAUR; Monocyte activation antigen Mo3; MO3; UPAR_MOUSE; UPAR_RAT; plasminogen activator, urokinase receptor; urokinase-type plasminogen activator (uPA) receptor; urokinase plasminogen activator surface receptor |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLAUR (HGNC:9053) |
|---|---|
| Synonyms | MO3, UPAR |
| Function | GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling (PubMed:1689240, PubMed:15677461). Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling (PubMed:17548516, PubMed:25168639, PubMed:28849762). This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling (PubMed:28849762). |
| Cellular Location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. Cell projection, invadopodium membrane; Lipid-anchor, GPI-anchor. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner |
| Tissue Location | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98997
