癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTK5/FRK Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P42685 |
| Other Accession | P42685 |
| Reactivity | Rat |
| Predicted | Pig, Human, Mouse, Rabbit, Chicken, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58254 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FRK/PTK5 |
| Epitope Specificity | 331-430/505 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. |
| SUBUNIT | Interacts (via the SH3-domain) with PTEN. Interacts with RB1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]. |
| Gene ID | 2444 |
|---|---|
| Other Names | GTK; PTK5; RAK; BSK; BSK/IYK; FRK_HUMAN; FRK; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; 2.7.10.2; FRK_MOUSE; Beta-cell Src-homology tyrosine kinase (BSK); Intestine tyrosine kinase; Iyk; FRK_RAT; Gastrointestinal-associated kinase (GASK); Gastrointestinal-associated tyrosine kinase (GTK); Gask; fyn related Src family tyrosine kinase; PTK5 protein tyrosine kinase 5; fyn-related Src family tyrosine kinase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FRK |
|---|---|
| Synonyms | PTK5, RAK |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery |
| Tissue Location | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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