癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DGKK Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q5KSL6 |
| Other Accession | Q5KSL6 |
| Reactivity | Rat |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 141829 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DGKK |
| Epitope Specificity | 181-280/1271 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the eukaryotic diacylglycerol kinase family.Contains 1 DAGKc domain.Contains 1 PH domain. Contains 2 phorbol-ester/DAG-type zinc fingers. |
| SUBUNIT | Does not form homooligomers. |
| Post-translational modifications | Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011] |
| Gene ID | 139189 |
|---|---|
| Other Names | Gm360; DGKK_HUMAN; DGKK; DAG kinase kappa; DGK-kappa; 142 kDa diacylglycerol kinase; Diglyceride kinase kappa; 2.7.1.107; diacylglycerol kinase kappa |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DGKK (HGNC:32395) |
|---|---|
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). |
| Cellular Location | Cell membrane; Peripheral membrane protein |
| Tissue Location | Expressed in testis, and to a lesser extent in placenta. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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