癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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PHLP Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q13371 |
| Other Accession | Q13371 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34282 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PHLP |
| Epitope Specificity | 51-150/301 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the phosducin family. |
| SUBUNIT | Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.Interacts with the CCT chaperonin complex. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008] |
| Gene ID | 5082 |
|---|---|
| Other Names | PhLP; 1200011E13Rik; PhLP1; Pdcl1; PHLP_HUMAN; PDCL; PHLOP1; PHLP_MOUSE; PHLP_RAT; phosducin like |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PDCL |
|---|---|
| Synonyms | PHLOP1, PhLP1 |
| Function | Acts as a positive regulator of hedgehog signaling and regulates ciliary function. [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. |
| Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99586
