癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAZ Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P56270 |
| Other Accession | P56270 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48608 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MAZ |
| Epitope Specificity | 211-310/477 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 6 C2H2-type zinc fingers. |
| SUBUNIT | Interacts with BPTF. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The Myc-associated zinc finger protein MAZ is a transcription factor that participates in both the initiation and termination of transcription of target genes. MAZ functions as a true transcriptional repressor in that it represses transcription independent of the c-Myc promoter. Both MAZ and SP1 bind to the parathyroid hormone (PTH)/ PTH-related peptide receptor promoter, thereby influencing the cell-specific expression of its gene product. MAZ and SP1 also regulate expression from the serotonin 1A receptor gene promoter, suggesting that MAZ may act on a variety of promoters through G-C rich sequences, which serve as binding sites for the SP1 family of transcription factors. Competition between SP1 and MAZ control tissue-specific expression of the PNMT gene. The interaction of MAZ with the transcriptional repressor FAC1 may affect gene regulation in neurodegeneration. MAZ also acts as a growth suppressor protein, in part by affecting the levels of key cell cycle regulatory proteins such as cyclin A and E. |
| Gene ID | 4150 |
|---|---|
| Other Names | PUR1; Pur-1; SAF-1; SAF-2; SAF-3; ZF87; ZNF801; Zif87; MAZI; MAZ_HUMAN; MAZ; Purine-binding transcription factor; Serum amyloid A-activating factor-1 (SAF-1); Transcription factor Zif87; Zinc finger protein 801; MAZ_MOUSE; MYC associated zinc finger protein; MYC-associated zinc finger protein (purine-binding transcription factor) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAZ |
|---|---|
| Synonyms | ZNF801 |
| Function | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. |
| Cellular Location | Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures |
| Tissue Location | Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99604
