癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MUM1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q2TAK8 |
| Other Accession | Q2TAK8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 78636 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MUM1/FLJ14868 |
| Epitope Specificity | 401-500/710 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the MUM1 family. |
| SUBUNIT | nteracts with TP53BP1 (via BRCT domain); the interaction is not dependent on its phosphorylation status. Binds nucleosomes. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Enables nucleosome binding activity. Involved in DNA repair and chromatin organization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jun 2025] |
| Gene ID | 84939 |
|---|---|
| Other Names | PWP3A_HUMAN; PWWP3A; Mutated melanoma-associated antigen 1 (MUM-1); PWWP domain-containing protein MUM1; Protein expandere; EXPAND1; MUM1; HSPC211; MUM-1; PWWP domain containing 3A, DNA repair factor; melanoma associated antigen (mutated) 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PWWP3A (HGNC:29641) |
|---|---|
| Function | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. |
| Cellular Location | Nucleus. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1 |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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