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ZRSR2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q15696 |
| Other Accession | Q15696 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58045 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZRSR2 |
| Epitope Specificity | 351-450/482 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 C3H1-type zinc fingers.Contains 1 RRM (RNA recognition motif) domain. |
| SUBUNIT | Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts (via RS domain) with SRSF1 and SRSF2. Interacts with U2AF2/U2AF65. |
| Post-translational modifications | Phosphorylated in the RS domain by SRPK1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008] |
| Gene ID | 8233 |
|---|---|
| Other Names | OFD21; U2AF1-RS2; U2AF1L2; U2AF1RS2; URP; ZC3H22; 35kDa; 5031411E02Rik; A230052C13Rik; RGD1559763; U2AFM_HUMAN; ZRSR2; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; Renal carcinoma antigen NY-REN-20; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2AF35-related protein (URP); U2AFM_MOUSE; zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2; U2 small nuclear RNA auxiliary factor 1-like 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZRSR2 |
|---|---|
| Synonyms | U2AF1-RS2, U2AF1L2, U2AF1RS2, URP |
| Function | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99831
