癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZRSR2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB |
|---|---|
| Primary Accession | Q15696 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58045 Da |
| Isotype | Rabbit IgG |
| Antigen Source | Human |
| Gene ID | 8233 |
|---|---|
| Antigen Region | 453-482 aa |
| Other Names | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2;U2AF1-RS2; U2AF1L2; U2AF1RS2; URP; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Renal carcinoma antigen NY-REN-20; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2AF35-related protein |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 |
| Target/Specificity | This ZRSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the C-terminal region of human ZRSR2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZRSR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZRSR2 |
|---|---|
| Synonyms | U2AF1-RS2, U2AF1L2, U2AF1RS2, URP |
| Function | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Pre-mRNA-binding protein required for splicing of both U2-and U12-type introns. Selectively interacts with the 3'-splice site of U2-and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
REFERENCES
Kitagawa K., et al. Genomics 30:257-263(1995).
Ross M.T., et al. Nature 434:325-337(2005).
Tronchere H., et al. Nature 388:397-400(1997).
Scanlan M.J., et al. Int. J. Cancer 83:456-464(1999).
Will C.L., et al. RNA 10:929-941(2004).
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