癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OAS1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P00973 |
| Other Accession | P00973 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46029 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human OAS1 |
| Epitope Specificity | 1-100/400 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the 2-5A synthase family. |
| SUBUNIT | Monomer. Homotetramer. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This protein is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. |
| Gene ID | 4938 |
|---|---|
| Other Names | E18/E16; IFI-4; IMD100; OIAS; OIASI; Oas1; Oas1g; OAS1_HUMAN; (2-5')oligo(A) synthase 1; 2-5A synthase 1; p46/p42 OAS; 2.7.7.84; OAS1A_MOUSE; Oas1a; (2-5')oligo(A) synthase 1A; 2-5A synthase 1A; p42 OAS; Oias1; OAS1_PIG; OAS1A_RAT; 2'-5'-oligoadenylate synthetase 1; 2', 5'-oligoadenylate synthetase 1 (40-46 kD); 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthase 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OAS1 |
|---|---|
| Synonyms | OIAS |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Catalyzes the formation of 2'-5'-oligoadenylates (2- 5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34145065, PubMed:34581622, PubMed:40010341). Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis (PubMed:40010341). Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (PubMed:40010341). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. |
| Cellular Location | Cytoplasm. Mitochondrion. Nucleus. Microsome Endoplasmic reticulum. Secreted {ECO:0000250|UniProtKB:Q29599}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. [Isoform p42]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS- CoV-2 replication. |
| Tissue Location | Expressed in lungs.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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