癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAM3B Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P58499 |
| Other Accession | P58499 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25982 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FAM3B |
| Epitope Specificity | 1-100/235 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the FAM3 family. |
| Post-translational modifications | 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. O-glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family. |
| Gene ID | 54097 |
|---|---|
| Other Names | 2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44; 9030624C24Rik; D16Jhu19e; FAM3B_HUMAN; FAM3B; Cytokine-like protein 2-21; Pancreatic-derived factor (PANDER); FAM3B_MOUSE; FAM3 metabolism regulating signaling molecule B; chromosome 21 open reading frame 11; family with sequence similarity 3 member B; pancreatic-derived factor |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FAM3B |
|---|---|
| Synonyms | C21orf11, C21orf76 |
| Function | Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. |
| Cellular Location | Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure |
| Tissue Location | Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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