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KHDRBS2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q5VWX1 |
| Other Accession | Q5VWX1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38927 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KHDRBS2 |
| Epitope Specificity | 121-220/349 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the KHDRBS family. Contains 1 KH domain. |
| SUBUNIT | Self-associates to form homooligomers. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KHDRBS2 (KH domain containing, RNA binding, signal transduction associated 2), is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. It induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer and may function as an adapter protein for Src kinases during mitosis. KHDRBS2 binds both poly(A) and poly(U) homopolymers. |
| Gene ID | 202559 |
|---|---|
| Other Names | KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1; 6330586C16Rik; Slim1; TG-RP135; Tg(LRRK2*R1441G)135Cjli; mSLM-1; KHDR2_HUMAN; KHDRBS2; Sam68-like mammalian protein 1 (SLM-1 | hSLM-1); KHDR2_MOUSE; Sam68-like mammalian protein 1 (SLM-1 | mSLM-1); KHDR2_RAT; Sam68-like mammalian protein 1 (SLM-1 | rSLM-1); KH RNA binding domain containing, signal transduction associated 2; KHDRBS2 3'UTR overlapping transcript 1; Sam68-like mammalian protein 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KHDRBS2 |
|---|---|
| Synonyms | SLM1 |
| Function | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre- mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WU01}. |
| Tissue Location | Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99924
