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TLR9 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NR96 |
| Other Accession | Q9NR96 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 115860 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TLR9 |
| Epitope Specificity | 951-1032/1032 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the Toll-like receptor family. Contains 26 LRR (leucine-rich) repeats. Contains 1 TIR domain. |
| SUBUNIT | Interacts with MYD88 via their respective TIR domains. Interacts with CNPY3. Interacts (via transmembrane domain) with UNC93B1. Interacts with BTK. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] |
| Gene ID | 54106 |
|---|---|
| Other Names | CD289; TLR9_HUMAN; TLR9; TLR9_MOUSE; toll like receptor 9; toll-like receptor 9 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,Flow-Cyt=1 µg /test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TLR9 |
|---|---|
| Function | Key component of innate and adaptive immunity (PubMed:14716310). TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms (PubMed:14716310). TLR9 is a nucleotide- sensing TLR which is activated by unmethylated cytidine-phosphate- guanosine (CpG) dinucleotides (PubMed:14716310). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028, PubMed:40980882). Also acts via ADCY7, leading to cyclic di-AMP (c-di- AMP) synthesis and activation of the NLRP3 inflammasome (By similarity). Plays a role in defense against systemic mouse cytomegalovirus infection (By similarity). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EQU3}. Early endosome membrane. Lysosome {ECO:0000250|UniProtKB:Q9EQU3} Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9EQU3}. Golgi apparatus membrane. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250|UniProtKB:Q9EQU3, ECO:0000269|PubMed:14716310, ECO:0000269|PubMed:38169466} |
| Tissue Location | Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP99938
