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Anti-CCN2 / CTGF Reference Antibody (pamrevlumab)

Recombinant Antibody

Anti- Human/Mouse/Monkey CTGF（ Pamrevlumab） In Vivo Mab on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti- Human/Mouse/Monkey CTGF（ Pamrevlumab） In Vivo Mab is 100%, determined by SEC-HPLC.
Immobilized human CTGF (His Tag, 2 µg/mL) can bind to Anti- Human/Mouse/Monkey CTGF（ Pamrevlumab） In Vivo Mab with an EC50 of 0.006105 ug/mL.
Anti- Human/Mouse/Monkey CTGF（ Pamrevlumab） In Vivo Mab inhibited the tumor growth of COLO205 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 39% at 40 mpk at D31.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P29279
Clonality	Monoclonal
Isotype	Human IgG1
Calculated MW	38091 Da

Additional Information
Target/Specificity	CCN2 / CTGF
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CCN2 (HGNC:2500)
Function	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor- induced DNA synthesis.
Cellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000250\|UniProtKB:P29268}. Secreted
Tissue Location	Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol