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Anti-ERBB3/ HER3 Reference Antibody (patritumab deruxtecan)

Recombinant Antibody

Anti-ERBB3/ HER3 Reference Antibody (Patritumab deruxtecan) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ERBB3/ HER3 Reference Antibody (Patritumab deruxtecan) is 99.19%, determined by SEC-HPLC.
Immobilized human HER3 His at 2 ug/mL can bind Anti-ERBB3/ HER3 Reference Antibody (Patritumab deruxtecan), EC50 is 0.044 ug/mL.
The drug-to-antibody ratio (DAR) of the Anti-ERBB3/ HER3 Reference Antibody (Patritumab deruxtecan) is 8.0.
Human ERBB3 / HER3 HEK293 Cell Line were stained with Anti-ERBB3/ HER3 Reference Antibody (Patritumab deruxtecan) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.39 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P21860
Reactivity	Human
Clonality	ADC
Isotype	IgG1
Calculated MW	148098 Da

Additional Information
Target/Specificity	ERBB3 / HER3
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Dxd
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ERBB3
Synonyms	HER3
Function	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
Cellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location	Epithelial tissues and brain.