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Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab)

Recombinant Antibody

Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab) is more than 95%, determined by SEC-HPLC.
Immobilized huaman CD70 FC at 4 ug/mL can bind Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab), EC50=0.08279 ug/mL.
HL-60 cells were stained with Anti-TNFSF7 / CD27L / CD70 Reference Antibody (cusatuzumab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.2727 ug/mL.
Human TNFSF7 / CD27L / CD70 CHO-K1 Cell Linewere stained with cusatuzumab and negative control protein respectively, washed and then followed by PE and analyzed with FACS,EC50=0.03451 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P32970
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	21118 Da

Additional Information
Target/Specificity	TNFSF7 / CD27L / CD70
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CD70 (HGNC:11937)
Function	Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70- CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864).
Cellular Location	Cell membrane; Single-pass type II membrane protein