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Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab)

Recombinant Antibody

Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab) is 95.93%, determined by SEC-HPLC.
Immobilized human CEACAM6 His at 2 ug/mL can bind Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab), EC50=0.005084 ug/mL.
Human CEACAM6 / CD66c EGFP-HEK293 Cell Line were stained with Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.02278 ug/mL.
Cynomolgus / Rhesus Macaque CEACAM6 / CD66c EGFP-HEK293 Cell Line were stained with Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.1263 ug/mL.
Human CEACAM6 / CD66c EGFP CHO-S Cell Line were stained with Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.01636 ug/mL.
Cynomolgus / Rhesus Macaque CEACAM6 / CD66c EGFP CHO-S Cell Line were stained with Anti-CEACAM6 / CD66c Reference Antibody (tinurilimab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.05674 ug/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P40199
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG2SA
Calculated MW	37237 Da

Additional Information
Target/Specificity	CEACAM6 / CD66c
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	CEACAM6 (HGNC:1818)
Function	Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:10910050, PubMed:11590190, PubMed:1378450, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:16204051, PubMed:2022629). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:11590190, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role in cell migration and cell adhesion to endothelial cells (PubMed:16204051).
Cellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Note=Localized to the apical glycocalyx surface.
Tissue Location	Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051).