Anti-FOLR1 / FRA Reference Antibody (mirvetuximab)

Recombinant Antibody

Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
The purity of Anti-FOLR1 / FRA Reference Antibody (mirvetuximab)is more than 100% ,determined by SEC-HPLC.
Immobilized human FRa His at 2 µg/mL can bind Anti-FOLR1 / FRA Reference Antibody (mirvetuximab)，EC50=0.01123 µg/mL
SKOV3 cells were stained with Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC168=0.03238 ug/mL
The endocytosis ratio mirvetuximab by Human Frα HEK 293 increased with the increase of antibody concentration, and the Internalization Rate (%) 75% at antibody concentration of 55 ng/mL.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, Kinetics, Animal Model
Primary Accession	P15328
Reactivity	Human, Mouse, Rat
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	150 KDa

Additional Information
Target/Specificity	FOLR1 / FRA
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO Cell
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.