> 首页 > 产品 > 一抗 > 基因重组 > Anti-MASP2 Reference Antibody (narsoplimab)

Anti-MASP2 Reference Antibody (narsoplimab)

Recombinant Antibody

Anti-MASP2 Reference Antibody (narsoplimab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-MASP2 Reference Antibody (narsoplimab) is 98.94%, determined by SEC-HPLC.
Immobilized human MASP 2A His at 2 ug/mL can bind Anti-MASP2 Reference Antibody (narsoplimab), EC50=0.006278 ug/mL.
C5b-C9 of the MBL pathway can be completely inhibited by Anti-MASP2 Reference Antibody (narsoplimab) with an IC50 of 0.7337 ug/mL.
Narsoplimab block C4b production,IC50=0.91 ug/mL.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O00187
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP
Calculated MW	75702 Da

Additional Information
Target/Specificity	MASP2
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	MASP2 {ECO:0000303\|PubMed:9087411, ECO:0000312\|HGNC:HGNC:6902}
Function	Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11527969, PubMed:22691502). The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface (PubMed:22691502, PubMed:22966085). MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates (PubMed:10946292, PubMed:22949645, PubMed:22966085, PubMed:9087411). Can activate prothrombin to thrombin (PubMed:39924859).
Cellular Location	Secreted.
Tissue Location	Plasma..