> 首页 > 产品 > 一抗 > 基因重组 > Anti-MMP9 Reference Antibody (andecaliximab)

Anti-MMP9 Reference Antibody (andecaliximab)

Recombinant Antibody

Anti-MMP9 Reference Antibody (andecaliximab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%.
The purity of Anti-MMP9 Reference Antibody (andecaliximab) is more than 95%, determined by SEC-HPLC.
Immobilized human MMP9 His at 2 ug/mL can bind Anti-MMP9 Reference Antibody (andecaliximab), EC50=0.006577 ug/mL.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P14780
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4SP
Calculated MW	78458 Da

Additional Information
Target/Specificity	MMP9
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	MMP9
Synonyms	CLG4B
Function	Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:12879005, PubMed:1480034, PubMed:2551898). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-\|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N- terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide.
Cellular Location	Secreted, extracellular space, extracellular matrix
Tissue Location	Detected in neutrophils (at protein level) (PubMed:7683678). Produced by normal alveolar macrophages and granulocytes.