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Anti-PLAUR / uPAR / CD87 Reference Antibody (ATN-658)

Recombinant Antibody

Anti-PLAUR / uPAR / CD87 Reference Antibody (ATN-658) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-PLAUR / uPAR / CD87 Reference Antibody (ATN-658) is 99.67%, determined by SEC-HPLC.
Immobilized huuPAR-Fc at 2 ug/mL can bind ATN-658, The EC50 is 0.05198 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q03405
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	36978 Da

Additional Information
Target/Specificity	PLAUR / uPAR / CD87
Endotoxin	< 0.001EU/ µg,determined by LAL method.
Conjugation	Unconjugated
Expression system	CHO
Format	Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	PLAUR (HGNC:9053)
Synonyms	MO3, UPAR
Function	GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling (PubMed:1689240, PubMed:15677461). Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling (PubMed:17548516, PubMed:25168639, PubMed:28849762). This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling (PubMed:28849762).
Cellular Location	[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. Cell projection, invadopodium membrane; Lipid-anchor, GPI-anchor. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner
Tissue Location	Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain