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>   首页   >   产品   >   一抗   >   精选抗体   >   Anti-PRAME Reference Antibody (Eureka patent anti-PRAME)   

Anti-PRAME Reference Antibody (Eureka patent anti-PRAME)

Recombinant Antibody

     
  • 1 - Anti-PRAME Reference Antibody (Eureka patent anti-PRAME) APR11017
    Anti-PRAME Reference Antibody (Eureka patent anti-PRAME) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%
  • 1 - Anti-PRAME Reference Antibody (Eureka patent anti-PRAME) APR11017
    The purity of Anti-PRAME Reference Antibody (Eureka patent anti-PRAME)is more than 95% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession P78395
Reactivity Human, Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 57890 Da
Additional Information
Target/Specificity PRAME
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name PRAME {ECO:0000303|PubMed:9047241, ECO:0000312|HGNC:HGNC:9336}
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254).
Cellular Location Nucleus. Chromosome. Cytoplasm Golgi apparatus. Cell membrane. Note=Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923).
Tissue Location Expressed in testis. Detected in samples of kidney, brain and skin.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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