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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-SERPINE1 Reference Antibody (Sanofi patent anti-PAI-1)   

Anti-SERPINE1 Reference Antibody (Sanofi patent anti-PAI-1)

Recombinant Antibody

     
  • 1 - Anti-SERPINE1 Reference Antibody (Sanofi patent anti-PAI-1) APR11030
    Anti-SERPINE1 Reference Antibody (Sanofi patent anti-PAI-1) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%
  • 1 - Anti-SERPINE1 Reference Antibody (Sanofi patent anti-PAI-1) APR11030
    The purity of Anti-SERPINE1 Reference Antibody (Sanofi patent anti-PAI-1)is more than 95% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession P05121
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 45060 Da
Additional Information
Target/Specificity SERPINE1
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name SERPINE1
Synonyms PAI1, PLANH1
Function Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Cellular Location Secreted.
Tissue Location Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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