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Anti-L-selectin Reference Antibody (Aselizumab)

Anti-L-selectin Reference Antibody (Aselizumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-L-selectin Reference Antibody (Aselizumab) is 98.3%, determined by SEC-HPLC.
PLVX-puro-mus-L-Selectin (CD62L)-FL cell line were stained with Aselizumabb and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 0.255 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	P14151
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG4
Calculated MW	42187 Da

Additional Information
Target/Specificity	L-selectin
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	SELL
Synonyms	LNHR, LYAM1
Function	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Cellular Location	Cell membrane; Single-pass type I membrane protein
Tissue Location	Expressed in B-cell lines and T-lymphocytes.