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Anti-FZD5 Reference Antibody (U.Toronto patent anti-FZD5)

Anti-FZD5 Reference Antibody (U.Toronto patent anti-FZD5) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-FZD5 Reference Antibody (U.Toronto patent anti-FZD5) is 98.6%, determined by SEC-HPLC.
HuFZD5-FL-His-EGFP-HEK293-A11 cell line were stained with U.Toronto patent anti-FZD5 and negative control protein respectively, washed and then followed by PE and analyzed with FACS, with the EC50 is 2.296 nM.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q13467
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1-EM
Calculated MW	64507 Da

Additional Information
Target/Specificity	FZD5
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	FZD5
Synonyms	C2orf31
Function	Receptor for Wnt proteins (PubMed:10097073, PubMed:20530549, PubMed:26908622, PubMed:9054360). Functions in the canonical Wnt/beta- catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses (PubMed:20530549). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (PubMed:26908622).
Cellular Location	Cell membrane; Multi-pass membrane protein {ECO:0000250\|UniProtKB:Q8CHL0}. Golgi apparatus membrane {ECO:0000250\|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250\|UniProtKB:Q9EQD0}. Synapse {ECO:0000250\|UniProtKB:Q8CHL0}. Perikaryon {ECO:0000250\|UniProtKB:Q8CHL0}. Cell projection, dendrite {ECO:0000250\|UniProtKB:Q8CHL0}. Cell projection, axon {ECO:0000250\|UniProtKB:Q8CHL0}. Note=Localized at the plasma membrane and also found at the Golgi apparatus. {ECO:0000250\|UniProtKB:Q9EQD0}