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Anti-ApoL1 Reference Antibody (Genentech patent anti-ApoL1)

Anti-ApoL1 Reference Antibody (Genentech patent anti-ApoL1) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ApoL1 Reference Antibody (Genentech patent anti-ApoL1) is 99.54%, determined by SEC-HPLC.
Immobilized hu-ApoL1-his, It’s target at 2 µg/mL can bind Genentech patent anti-ApoL1, EC50= 1.401 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O14791
Reactivity	Human
Clonality	Monoclonal
Isotype	Rabbit-IgG-mut1
Calculated MW	43974 Da

Additional Information
Target/Specificity	ApoL1
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	APOL1 {ECO:0000303\|PubMed:19997494}
Synonyms	APOL
Function	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in killing Trypanosoma brucei by forming pores in parasite lysosomal membranes and sensitizing T.brucei to oxidation-stimulated osmotic lysis (PubMed:12621437, PubMed:16020735, PubMed:19997494, PubMed:26645690, PubMed:7723792).
Cellular Location	Secreted. Note=Internalized through the endocytic pathway into the lysosomes of Trypanosoma brucei
Tissue Location	Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen