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Anti-ADMAST4 Reference Antibody (GSK patent anti-ADMAST4)

Anti-ADMAST4 Reference Antibody (GSK patent anti-ADMAST4) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-ADMAST4 Reference Antibody (GSK patent anti-ADMAST4) is 100%, determined by SEC-HPLC.
Immobilized hu-ADAMTS4(O75173)-his-Stock solution, It’s target at 2 µg/mL can bind GSK patent anti-ADMAST4, EC50= 0.07513 µg/mL.

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	O75173
Reactivity	Human
Clonality	Monoclonal
Isotype	IgG1
Calculated MW	90197 Da

Additional Information
Target/Specificity	ADMAST4
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	ADAMTS4
Synonyms	KIAA0688
Function	Cleaves aggrecan, a cartilage proteoglycan, at the '392- Glu-\|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.
Cellular Location	Secreted, extracellular space, extracellular matrix
Tissue Location	Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)