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Anti-IL-19 Reference Antibody (Cheng Kung U. patent anti-IL-19)

Anti-IL-19 Reference Antibody (Cheng Kung U. patent anti-IL-19) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The purity of Anti-IL-19 Reference Antibody (Cheng Kung U. patent anti-IL-19) is 96.43%, determined by SEC-HPLC.
Immobilized hu-IL-19(Q9UHD0)-his, It’s target at 2 µg/mL can bind Cheng Kung U. patent anti-IL-19, EC50= 0.05822 µg/mL.

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Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	Functional assay, Kinetics (SPR), Kinetics (BLI), FACS, E, FTA
Primary Accession	Q9UHD0
Reactivity	Human
Clonality	Monoclonal
Isotype	mIgG1-TW-DD
Calculated MW	20452 Da

Additional Information
Target/Specificity	IL-19
Expression system	CHO

For Research Use Only. Not For Use In Diagnostic Procedures.

Patent Notice: The variable region sequence of this antibody is derived from a published third-party patent. This product is manufactured independently as a Research Use Only (RUO) reagent and is not licensed, sponsored, or endorsed by the patent holder. It is intended solely for research purposes. Customers considering any commercial, diagnostic, or therapeutic use should independently evaluate freedom-to-operate with respect to relevant third-party patents.

Protein Information
Name	IL19
Synonyms	ZMDA1
Function	Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763).
Cellular Location	Secreted.