癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DRAK1 Antibody
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Application 
| WB, IF, ICC, E |
|---|---|
| Primary Accession | Q9UEE5 |
| Other Accession | Q9UEE5, 14423930 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 46558 Da |
| Conjugate | Unconjugated |
| Application Notes | DRAK1 antibody can be used for detection of DRAK1 by Western blot at 1 µg/mL. An approximately 50 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 2 µg/mL. For immunofluorescence start at 10 µg/mL. |
| Gene ID | 9263 |
|---|---|
| Other Names | DRAK1 Antibody: DRAK1, DRAK1, DAP kinase-related apoptosis-inducing protein kinase 1, serine/threonine kinase 17a |
| Target/Specificity | STK17A; No cross responses to DRAK2, DAP or ZIP kinases. |
| Reconstitution & Storage | DRAK1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | DRAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STK17A |
|---|---|
| Synonyms | DRAK1 |
| Function | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DRAK1 Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
REFERENCES
Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71
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