癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EphA10 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q5JZY3 |
| Other Accession | NP_001092909, 150456460 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 109716 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | EphA10 antibody can be used for detection of EphA10 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 284656 |
|---|---|
| Other Names | Ephrin type-A receptor 10, 2.7.10.1, EPHA10 |
| Target/Specificity | EPHA10; |
| Reconstitution & Storage | EphA10 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | EphA10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPHA10 |
|---|---|
| Function | Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. |
| Cellular Location | [Isoform 1]: Cell membrane; Single- pass type I membrane protein [Isoform 2]: Secreted. |
| Tissue Location | Mainly expressed in testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EphA10 Antibody: Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility of neuronal and endothelial cells in central nervous system function and in development. Eph receptors can be divided into two subgroups: EphA and EphB. In mammals, the EphA class consists of eight members (EphA 1-7 and 10) that in general bind to ephrin-A members linked to the cell membrane through a glycosylphosphatidylinositol linkage. The EphB class consists of six members (EphB 1-6) that in general bind ephrin-B members that transverse the cell membrane. The Ephrin / EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Recent studies show that Eph/EFN might be relevant in normal B-cell biology and could represent new potential prognostic markers and therapeutic targets for CLL.
REFERENCES
Flanagan JG and Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci.1998;.21:309-45.
Frisen J, Holmberg J, and Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J.1999; 18:5159-65.
Eph Nomenclature Committee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell1997; 90:403-4.
Holder N and Klein R. Eph receptors and ephrins: effectors of morphogenesis, Development1999; 126:2033-44.
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