癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IA-6 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96T92 |
| Other Accession | AAI30380, 120659844 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 59491 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | IA-6 antibody can be used for detection of IA-6 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 84684 |
|---|---|
| Other Names | Insulinoma-associated protein 2, Zinc finger protein IA-6, INSM2, IA6 |
| Target/Specificity | INSM2; |
| Reconstitution & Storage | IA-6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | IA-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | INSM2 |
|---|---|
| Synonyms | IA6 |
| Function | May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
IA-6 Antibody: IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription.
REFERENCES
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet.2004; 36:40-5.
Wildner H, Gierl MS, Strehle M, et al. Insm (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympathoadrenal lineage. Dev.2008; 135:473-81.
Trembleau S, Penna G, Grigori S, et al. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes. J. Immunol.2000; 165:6748-55.
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