癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARHGAP39 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9C0H5 |
| Other Accession | NP_079527, 58331179 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 121286 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | ARHGAP39 antibody can be used for detection of ARHGAP39 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 80728 |
|---|---|
| Other Names | Rho GTPase-activating protein 39, ARHGAP39, KIAA1688 |
| Target/Specificity | ARHGAP39; ARHGAP39 antibody is predicted to not cross-react with other RhoGAP protein family members. |
| Reconstitution & Storage | ARHGAP39 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | ARHGAP39 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGAP39 |
|---|---|
| Synonyms | KIAA1688 |
| Cellular Location | Nucleus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ARHGAP39 Antibody: Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP39 (Rho GTPase activating protein 39) is a 1, 083 amino acid nuclear protein that contains one MyTH4 domain, one Rho GAP domain and two WW domains. It is encoded by a gene located on human chromosome 8, which is associated with a variety of diseases and malignancies. ARHGAP39 regulates robo signaling and plays important roles in axon guidance.
REFERENCES
Takai Y, Sasaki T, and Matozaki T. Small GTP-binding proteins. Physiol. Rev. 2001; 81:153-208.
Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc. Natl. Acad. Sci. USA 2005; 102:4613-8
Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature 2006; 439:331-5
Lundström A, Gallio M, Englund C, et al. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 2004; 18:2161-71.
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