癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MS4A6A Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q9H2W1 |
| Other Accession | NP_071744, 23238238 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 26943 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | MS4A6A antibody can be used for detection of MS4A6A by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 64231 |
|---|---|
| Other Names | Membrane-spanning 4-domains subfamily A member 6A, CD20 antigen-like 3, Four-span transmembrane protein 3, MS4A6A, 4SPAN3, CD20L3, MS4A6 |
| Target/Specificity | MS4A6A; At least three isoforms of MS4A6A are known to exist; this antibody will detect the two longer isoforms. MS4A6A antibody is predicted to not cross-react with MS4A family members. |
| Reconstitution & Storage | MS4A6A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | MS4A6A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MS4A6A |
|---|---|
| Synonyms | 4SPAN3, CD20L3, MS4A6 |
| Function | May be involved in signal transduction as a component of a multimeric receptor complex. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Variable expression in some B-cell, myelomonocytic, and erythroleukemia cell lines |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MS4A6A Antibody: The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other genes encoding membrane proteins, most having characteristic tetraspanning topology and similar intron/exon splice boundaries. All family members display unique expression patterns among hematopoietic cells and non-lymphoid tissues. The function of MS4A6A has been suggested to be involved in signal transduction as a component of a multimeric receptor complex in Alzheimer's disease and cancer.
REFERENCES
Liang Y and Tedder TF. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 2001; 72:119-27
Ishibashi K, Suzuki M, Sasaki S, et al. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 2001; 264:87-93.
Antúnez C, Boada M, Gonzalez-Pérez A, et al. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Med. 2011; 3:33
Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011; 43:429-35.
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