癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRB1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P82279 |
| Other Accession | NP_001180569, 302370926 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 154183 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | CRB1 antibody can be used for detection of CRB1 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 23418 |
|---|---|
| Other Names | Protein crumbs homolog 1, CRB1 |
| Target/Specificity | CRB1; Alternatively spliced transcript variants have been observed. CRB1 antibody i spredicted to not cross-react with CRB2. |
| Reconstitution & Storage | CRB1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | CRB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRB1 (HGNC:2343) |
|---|---|
| Function | Plays a role in photoreceptor morphogenesis in the retina (By similarity). May maintain cell polarization and adhesion (By similarity). |
| Cellular Location | [Isoform 1]: Apical cell membrane {ECO:0000250|UniProtKB:Q8VHS2}; Single-pass type I membrane protein. Secreted. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8VHS2} Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHS2} |
| Tissue Location | Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye (PubMed:15914641) Expressed at the outer limiting membrane and apical to adherens junctions in the retina (PubMed:15914641) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CRB1 Antibody: CRB1 (Crumbs homolog 1) plays a role in photoreceptor morphogenesis in the retina. It may maintain cell polarization and adhesion. CRB1 is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. The first identified human homolog, CRB1, is expressed in retina and some parts of the brain, leaving room for another homolog to function in epithelial tissues. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.
REFERENCES
Van de Pavert SA, Kantardzhieva A, Malysheva A, et al. Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J. Cell Sci. 2004; 117:4169-77.
Van de Pavert SA, Sanz AS, Aartsen WM, et al. Crb1 is a determinant of retinal apical Muller glia cell features. Glia 2007; 55:1486-97.
Den Hollander AI, Johnson K, de Kok YJ, et al. CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila. Hum. Mol. Genet. 2001; 10:2767-73.
Bujakowska K, Audo I, Mohand-Said S, et al. CRB1 mutations in inherited retinal dystrophies. Hum. Mutat. 2012; 33:306-15.
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