癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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SIDT2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NBJ9 |
| Other Accession | NP_001035545, 94721340 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 94454 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SIDT2 antibody can be used for detection of SIDT2 by Western blot at 0.5 - 1 µg/mL. |
| Gene ID | 51092 |
|---|---|
| Other Names | SID1 transmembrane family member 2, SIDT2 |
| Target/Specificity | SIDT2; Multiple isoforms of SIDT2 are known to exist; this antibody is predicted to not cross-react with other members of the SID1 transmembrane family. |
| Reconstitution & Storage | SIDT2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | SIDT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIDT2 |
|---|---|
| Function | Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Cell membrane. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:28277980} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SIDT2 Antibody: The SID1 transmembrane family member (SIDT2) is a highly glycosylated, multipass transmembrane protein that localizes to the lysosomal membrane. SIDT2 is highly expressed in liver, brain and kidney, with no or little expression in skeletal muscles, heart or other tissues. Little is known of the function of SIDT2.
REFERENCES
Jialin G, Xuefan G, and Huiwen Z. SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal membrane protein. Biochem. Biophys. Res. Commun. 2010; 402:588-94.
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