癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IQSEC2 Antibody
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- 实验流程
- 背景知识
Application 
| WB, E, IHC-P |
|---|---|
| Primary Accession | Q5JU85 |
| Other Accession | NP_001104595, 162138911 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 162784 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | IQSEC2 antibody can be used for detection of IQSEC2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
| Gene ID | 23096 |
|---|---|
| Other Names | IQ motif and SEC7 domain-containing protein 2, IQSEC2, KIAA0522 |
| Target/Specificity | IQSEC2; IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist; this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1. |
| Reconstitution & Storage | IQSEC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | IQSEC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IQSEC2 (HGNC:29059) |
|---|---|
| Function | Is a guanine nucleotide exchange factor (GEF) for small GTPases of the ARF family, promoting activation of specific ARFs through exchange of GDP for GTP (PubMed:26793055, PubMed:37787765). In vitro, it has GEF activity towards ARF1 and ARF6 (PubMed:30842726, PubMed:37787765, PubMed:38200111). Is involved in the regulation of synaptic transmission and plasticity, controlling trafficking and removal of AMPA receptors GRIA2/GLUA2 and GRIA3/GLUA3 at synapses (PubMed:27009485, PubMed:30842726). Additionally, it may regulate the assembly of the post-synaptic density in a Ca(2+)-dependent manner, operating independently of its GEF activity (PubMed:41123449). |
| Cellular Location | Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5DU25}. Postsynaptic density |
| Tissue Location | Widely expressed. [Isoform 3]: Predominantly expressed in non-neural tissues. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2). IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1). Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3).
REFERENCES
Murphy JA, Jensen ON, and Walikonis RS. BRAG1, a SEC7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses. Brain Res. 2006; 1120:35-45.
Someya A, Sata M, Takeda K, et al. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosy
Shoubridge C, Tarpey PS, Abidi F, et al. Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual ability. Nat. Genet. 2010; 42:486-8.
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